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for the SURMOUNT-5 Trial Investigators

Semaglutide carries a boxed warning for thyroid C-cell tumors in rodent studies and is contraindicated in people with MTC or MEN 2

GLP-1 plays a central role in regulating appetite, blood sugar, and digestion, but in many people particularly those with obesity or metabolic dysfunction this hormonal signaling is impaired or insufficient to maintain a healthy weight

Taking 1000 to 2000 mcg orally daily allows approximately 1 to 3 percent passive absorption even without intrinsic factor

There was no difference in blood glucose, hematological and biochemical parameters between treatments, however animals that received exenatide lost more weight than those who received saline and needed lower insulin doses to maintain blood glucose (Scuderi et al., 2018)